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Michael E Brune Selected Research

9- (3- bromo- 4- fluorophenyl)- 2,3,5,6,7,9- hexahydrothieno(3,2- b)quinolin- 8(4H)- one 1,1-dioxide

10/2002(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. II. in vivo characterization.

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Michael E Brune Research Topics

Disease

6Overactive Urinary Bladder (Overactive Bladder)
11/2007 - 10/2002
4Obesity
02/2008 - 03/2005
3Weight Loss (Weight Reduction)
02/2008 - 04/2006
3Body Weight (Weight, Body)
07/2006 - 03/2005
2Urinary Bladder Neck Obstruction (Bladder Neck Obstruction)
01/2003 - 10/2002
1Alzheimer Disease (Alzheimer's Disease)
04/2011
1Metabolic Diseases (Metabolic Disease)
02/2008
1Mood Disorders (Mood Disorder)
07/2006
1Bone Resorption
01/2006
1Lower Urinary Tract Symptoms
09/2004
1Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
02/2002
1Hypotension (Low Blood Pressure)
02/2002

Drug/Important Bio-Agent (IBA)

5Adenosine Triphosphate (ATP)IBA
02/2006 - 10/2002
2GhrelinIBA
04/2006 - 04/2006
2fiduxosinIBA
02/2002 - 02/2002
1GlucocorticoidsIBA
04/2011
1ChylomicronsIBA
02/2008
1LipidsIBA
02/2008
1Triglycerides (Triacylglycerol)IBA
02/2008
1dicyandiamido (cyanoguanidine)IBA
11/2007
1KATP ChannelsIBA
11/2007
1AmidesIBA
07/2006
1antineoplaston A10 (A 10)IBA
07/2006
1melanin-concentrating hormone (melanin concentrating hormone)IBA
07/2006
1Growth Hormone (Somatotropin)IBA
04/2006
1Insulin (Novolin)FDA Link
04/2006
1LeptinIBA
04/2006
1Vitamin DFDA LinkGeneric
01/2006
11,25-dihydroxyvitamin DIBA
01/2006
1IndazolesIBA
06/2005
1melanin-concentrating hormone receptorIBA
06/2005
1Urea (Carbamide)FDA LinkGeneric
06/2005
1LigandsIBA
03/2005
1ciproxifanIBA
03/2005
1Histamine H3 Receptors (Histamine H3 Receptor)IBA
03/2005
1thioperamideIBA
03/2005
1imidazoleIBA
03/2005
1A-151892IBA
09/2004
1Tolterodine Tartrate (Detrol)FDA Link
01/2003
1PotassiumIBA
10/2002
19- (3- bromo- 4- fluorophenyl)- 2,3,5,6,7,9- hexahydrothieno(3,2- b)quinolin- 8(4H)- one 1,1-dioxideIBA
10/2002
11,4-dihydropyridine (dihydropyridine)IBA
10/2002
1Terazosin (Hytrin)FDA LinkGeneric
02/2002
1Tamsulosin (Flomax)FDA LinkGeneric
02/2002

Therapy/Procedure

1Oral Administration
02/2007
1Therapeutics
01/2003